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Ribosomes stalling on uORF1 in the Xenopus Cx41 5′ UTR inhibit downstream translation initiation

Translation of Xenopus laevis Connexin41 mRNA is strongly controlled by the three upstream open reading frames (uORFs) in its 5′ untranslated region. Mutation of uAUG1 into AAG induced a 100-fold increase in translation of a green fluorescent protein (GFP) reporter ORF. The termination codon of uORF...

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Bibliografske podrobnosti
Main Authors: Meijer, Hedda A., Thomas, Adri A. M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC162333/
https://ncbi.nlm.nih.gov/pubmed/12799445
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