Expansion of human SCID-repopulating cells under hypoxic conditions

It has been proposed that bone marrow (BM) hematopoietic stem and progenitor cells are distributed along an oxygen (O(2)) gradient, where stem cells reside in the most hypoxic areas and proliferating progenitors are found in O(2)-rich areas. However, the effects of hypoxia on human hematopoietic ste...

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Main Authors: Danet, Guénahel H., Pan, Yi, Luongo, Jennifer L., Bonnet, Dominique A., Simon, M. Celeste
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2003
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC162287/
https://ncbi.nlm.nih.gov/pubmed/12840067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317669
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