Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA

Locked nucleic acids (LNAs) and double-stranded small interfering RNAs (siRNAs) are rather new promising antisense molecules for cell culture and in vivo applications. Here, we compare LNA–DNA–LNA gapmer oligonucleotides and siRNAs with a phosphorothioate and a chimeric 2′-O-methyl RNA–DNA gapmer wi...

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Autores principales: Grünweller, Arnold, Wyszko, Eliza, Bieber, Birgit, Jahnel, Ricarda, Erdmann, Volker A., Kurreck, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2003
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC162243/
https://ncbi.nlm.nih.gov/pubmed/12799446
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