Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA

Locked nucleic acids (LNAs) and double-stranded small interfering RNAs (siRNAs) are rather new promising antisense molecules for cell culture and in vivo applications. Here, we compare LNA–DNA–LNA gapmer oligonucleotides and siRNAs with a phosphorothioate and a chimeric 2′-O-methyl RNA–DNA gapmer wi...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Grünweller, Arnold, Wyszko, Eliza, Bieber, Birgit, Jahnel, Ricarda, Erdmann, Volker A., Kurreck, Jens
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2003
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12799446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg409
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