Nitric Oxide Increases the Decay of Matrix Metalloproteinase 9 mRNA by Inhibiting the Expression of mRNA-Stabilizing Factor HuR

Dysregulation of extracellular matrix turnover is an important feature of many inflammatory processes. Rat renal mesangial cells express high levels of matrix metalloproteinase 9 (MMP-9) in response to inflammatory cytokines such as interleukin-1 beta. We demonstrate that NO does strongly destabiliz...

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Bibliografiske detaljer
Main Authors: Akool, El-Sayed, Kleinert, Hartmut, Hamada, Farid M. A., Abdelwahab, Mohamed H., Förstermann, Ulrich, Pfeilschifter, Josef, Eberhardt, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC162218/
https://ncbi.nlm.nih.gov/pubmed/12832476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.4901-4916.2003
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