Nitric Oxide Increases the Decay of Matrix Metalloproteinase 9 mRNA by Inhibiting the Expression of mRNA-Stabilizing Factor HuR

Dysregulation of extracellular matrix turnover is an important feature of many inflammatory processes. Rat renal mesangial cells express high levels of matrix metalloproteinase 9 (MMP-9) in response to inflammatory cytokines such as interleukin-1 beta. We demonstrate that NO does strongly destabiliz...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Akool, El-Sayed, Kleinert, Hartmut, Hamada, Farid M. A., Abdelwahab, Mohamed H., Förstermann, Ulrich, Pfeilschifter, Josef, Eberhardt, Wolfgang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2003
Schlagworte:	Gene Expression
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832476/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.4901-4916.2003
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