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An approach to gene-specific transcription inhibition using oligonucleotides complementary to the template strand of the open complex

The single-stranded region of DNA within the open complex of transcriptionally active genes provides a unique target for the design of gene-specific transcription inhibitors. Using the Escherichia coli lac UV5 and trp EDCBA promoters as in vitro models of open complex formation, we have identified t...

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Bibliografiske detaljer
Main Authors: Milne, Lisa, Xu, Yue, Perrin, David M., Sigman, David S.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16205/
https://ncbi.nlm.nih.gov/pubmed/10716709
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