A transcription inhibitor specific for unwound DNA in RNA polymerase-promoter open complexes.

The kinetically component open complexes formed at prokaryotic and eukaryotic transcription start sites are efficiently nicked by the chemical nuclease activity of the 2:1 1,10-phenanthroline-copper(I) complex [(OP)2Cu+] and hydrogen peroxide. This reaction specificity has been attributed to the cre...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Mazumder, A, Perrin, D M, Watson, K J, Sigman, D S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8367475/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.17.8140
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