Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition.
The ability of phosphorothioate (POS) oligonucleotides to recognise and bind to homopurine-homopyrimidine DNA double-stranded sites via triple helix formation has been investigated. It has been found that the homologous pyrimidine POS sequences Y11-Si (i = 0, 1,2,3,4,10), which have been obtained by...
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| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1994
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| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC523725/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8078767/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.16.3322 |
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