Oligonucleotide N3'-->P5' phosphoramidates as antisense agents.

Uniformly modified oligonucleotide N3'-->P5' phosphoramidates, where every 3'-oxygen is replaced by a 3'-amino group, were synthesized. These compounds have very high affinity to single-stranded RNAs and thus have potential utility as antisense agents. As was shown in this stu...

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Hlavní autoři: Gryaznov, S, Skorski, T, Cucco, C, Nieborowska-Skorska, M, Chiu, C Y, Lloyd, D, Chen, J K, Koziolkiewicz, M, Calabretta, B
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC145826/
https://ncbi.nlm.nih.gov/pubmed/8628685
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