Oligonucleotide N3'-->P5' phosphoramidates as antisense agents.

Uniformly modified oligonucleotide N3'-->P5' phosphoramidates, where every 3'-oxygen is replaced by a 3'-amino group, were synthesized. These compounds have very high affinity to single-stranded RNAs and thus have potential utility as antisense agents. As was shown in this study, the oligonucleotide...

Descripción completa

Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Autores principales:	Gryaznov, S, Skorski, T, Cucco, C, Nieborowska-Skorska, M, Chiu, C Y, Lloyd, D, Chen, J K, Koziolkiewicz, M, Calabretta, B
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145826/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628685/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.8.1508
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!