Oligonucleotide N3'-->P5' phosphoramidates as antisense agents.

Uniformly modified oligonucleotide N3'-->P5' phosphoramidates, where every 3'-oxygen is replaced by a 3'-amino group, were synthesized. These compounds have very high affinity to single-stranded RNAs and thus have potential utility as antisense agents. As was shown in this study, the oligonucleotide...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Gryaznov, S, Skorski, T, Cucco, C, Nieborowska-Skorska, M, Chiu, C Y, Lloyd, D, Chen, J K, Koziolkiewicz, M, Calabretta, B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145826/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628685/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.8.1508
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