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Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition.
The ability of phosphorothioate (POS) oligonucleotides to recognise and bind to homopurine-homopyrimidine DNA double-stranded sites via triple helix formation has been investigated. It has been found that the homologous pyrimidine POS sequences Y11-Si (i = 0, 1,2,3,4,10), which have been obtained by...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
1994
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC523725/ https://ncbi.nlm.nih.gov/pubmed/8078767 |
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