CTNNB1 Mutations and Overexpression of Wnt/β-Catenin Target Genes in WT1-Mutant Wilms’ Tumors

Gain-of-function mutations in exon 3 of β-catenin (CTNNB1) are specific for Wilms’ tumors that have lost WT1, but 50% of WT1-mutant cases lack such “hot spot” mutations. To ask whether stabilization of β-catenin might be essential after WT1 loss, and to identify downstream target genes, we compared...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Li, Chi-Ming, Kim, Connie E., Margolin, Adam A., Guo, Meirong, Zhu, Jimmy, Mason, Jacqueline M., Hensle, Terrence W., Murty, Vundavalli V.V.S., Grundy, Paul E., Fearon, Eric R., D’Agati, Vivette, Licht, Jonathan D., Tycko, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2004
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618727/
https://ncbi.nlm.nih.gov/pubmed/15579438
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados