CTNNB1 Mutations and Overexpression of Wnt/β-Catenin Target Genes in WT1-Mutant Wilms’ Tumors

Gain-of-function mutations in exon 3 of β-catenin (CTNNB1) are specific for Wilms’ tumors that have lost WT1, but 50% of WT1-mutant cases lack such “hot spot” mutations. To ask whether stabilization of β-catenin might be essential after WT1 loss, and to identify downstream target genes, we compared...

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Detaylı Bibliyografya
Asıl Yazarlar: Li, Chi-Ming, Kim, Connie E., Margolin, Adam A., Guo, Meirong, Zhu, Jimmy, Mason, Jacqueline M., Hensle, Terrence W., Murty, Vundavalli V.V.S., Grundy, Paul E., Fearon, Eric R., D’Agati, Vivette, Licht, Jonathan D., Tycko, Benjamin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2004
Konular:
Original Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618727/
https://ncbi.nlm.nih.gov/pubmed/15579438
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