Wilms Tumor Suppressor, WT1, Suppresses Epigenetic Silencing of the β-Catenin Gene

The mammalian kidney is derived from progenitor cells in intermediate mesoderm. During embryogenesis, progenitor cells expressing the Wilms tumor suppressor gene, WT1, are induced to differentiate in response to WNT signals from the ureteric bud. In hereditary Wilms tumors, clonal loss of WT1 preclu...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Akpa, Murielle M., Iglesias, Diana M., Chu, Lee Lee, Cybulsky, Marta, Bravi, Cristina, Goodyer, Paul R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303678/
https://ncbi.nlm.nih.gov/pubmed/25331950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.573576
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