Wilms Tumor Suppressor, WT1, Cooperates with MicroRNA-26a and MicroRNA-101 to Suppress Translation of the Polycomb Protein, EZH2, in Mesenchymal Stem Cells

Hereditary forms of Wilms arise from developmentally arrested clones of renal progenitor cells with biallelic mutations of WT1; recently, it has been found that Wilms tumors may also be associated with biallelic mutations in DICER1 or DROSHA, crucial for miRNA biogenesis. We have previously shown th...

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Vydáno v:J Biol Chem
Hlavní autoři: Akpa, Murielle M., Iglesias, Diana, Chu, LeeLee, Thiébaut, Antonin, Jentoft, Ida, Hammond, Leah, Torban, Elena, Goodyer, Paul R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759161/
https://ncbi.nlm.nih.gov/pubmed/26655220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678029
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