Long-Term Accumulation of Amyloid-β, β-Secretase, Presenilin-1, and Caspase-3 in Damaged Axons Following Brain Trauma

Plaques composed of amyloid β (Aβ) have been found within days following brain trauma in humans, similar to the hallmark plaque pathology of Alzheimer’s disease (AD). Here, we evaluated the potential source of this Aβ and long-term mechanisms that could lead to its production. Inertial brain injury...

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Hauptverfasser: Chen, Xiao-Han, Siman, Robert, Iwata, Akira, Meaney, David F., Trojanowski, John Q., Smith, Douglas H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2004
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618579/
https://ncbi.nlm.nih.gov/pubmed/15277212
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