The Oncogenic Activity of RET Point Mutants for Follicular Thyroid Cells May Account for the Occurrence of Papillary Thyroid Carcinoma in Patients Affected by Familial Medullary Thyroid Carcinoma

Activating germ-line point mutations in the RET receptor are responsible for multiple endocrine neoplasia type 2-associated medullary thyroid carcinoma (MTC), whereas somatic RET rearrangements are prevalent in papillary thyroid carcinomas (PTCs). Some rare kindreds, carrying point mutations in RET,...

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Main Authors: Melillo, Rosa Marina, Cirafici, Anna Maria, De Falco, Valentina, Bellantoni, Marie, Chiappetta, Gennaro, Fusco, Alfredo, Carlomagno, Francesca, Picascia, Antonella, Tramontano, Donatella, Tallini, Giovanni, Santoro, Massimo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2004
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618571/
https://ncbi.nlm.nih.gov/pubmed/15277225
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