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Interaction of Bunyamwera Orthobunyavirus NSs Protein with Mediator Protein MED8: a Mechanism for Inhibiting the Interferon Response

The NSs protein of Bunyamwera virus (Bunyaviridae) is an antiapoptotic interferon antagonist involved in silencing host protein expression by interfering with mRNA synthesis. Here, we show that the ability to inhibit both host transcription and the interferon response is linked to interaction of NSs...

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Autori principali: Léonard, Vincent H. J., Kohl, Alain, Hart, Timothy J., Elliott, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617248/
https://ncbi.nlm.nih.gov/pubmed/16973571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00822-06
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