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Interaction of Bunyamwera Orthobunyavirus NSs Protein with Mediator Protein MED8: a Mechanism for Inhibiting the Interferon Response

The NSs protein of Bunyamwera virus (Bunyaviridae) is an antiapoptotic interferon antagonist involved in silencing host protein expression by interfering with mRNA synthesis. Here, we show that the ability to inhibit both host transcription and the interferon response is linked to interaction of NSs...

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Bibliografiske detaljer
Main Authors: Léonard, Vincent H. J., Kohl, Alain, Hart, Timothy J., Elliott, Richard M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617248/
https://ncbi.nlm.nih.gov/pubmed/16973571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00822-06
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