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Interaction of Bunyamwera Orthobunyavirus NSs Protein with Mediator Protein MED8: a Mechanism for Inhibiting the Interferon Response

The NSs protein of Bunyamwera virus (Bunyaviridae) is an antiapoptotic interferon antagonist involved in silencing host protein expression by interfering with mRNA synthesis. Here, we show that the ability to inhibit both host transcription and the interferon response is linked to interaction of NSs...

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Détails bibliographiques
Auteurs principaux: Léonard, Vincent H. J., Kohl, Alain, Hart, Timothy J., Elliott, Richard M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617248/
https://ncbi.nlm.nih.gov/pubmed/16973571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00822-06
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