Cidofovir Resistance in Vaccinia Virus Is Linked to Diminished Virulence in Mice

Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC)] is recognized as a promising drug for the treatment of poxvirus infections, but drug resistance can arise by a mechanism that is poorly understood. We show here that in vitro selection for high levels of resistance to HPMPC prod...

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Bibliografiske detaljer
Main Authors: Andrei, Graciela, Gammon, Don B., Fiten, Pierre, De Clercq, Erik, Opdenakker, Ghislain, Snoeck, Robert, Evans, David H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617232/
https://ncbi.nlm.nih.gov/pubmed/16973545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00605-06
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