Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin

A broad variety of herpes simplex virus type 1 clones was selected under a single round of high-dose selection with brivudin. Mutations in the thymidine kinase (TK) genes consisted of 42% frameshift mutations within homopolymer repeats of G's and C's and single nucleotide substitutions (58...

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Detalhes bibliográficos
Main Authors: Andrei, Graciela, Balzarini, Jan, Fiten, Pierre, De Clercq, Erik, Opdenakker, Ghislain, Snoeck, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1082774/
https://ncbi.nlm.nih.gov/pubmed/15827202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.9.5863-5869.2005
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