Mechanism of Antiviral Drug Resistance of Vaccinia Virus: Identification of Residues in the Viral DNA Polymerase Conferring Differential Resistance to Antipoxvirus Drugs

The acyclic nucleoside phosphonate (ANP) family of drugs shows promise as therapeutics for treating poxvirus infections. However, it has been questioned whether the utility of these compounds could be compromised through the intentional genetic modification of viral sequences by bioterrorists or the...

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Библиографические подробности
Главные авторы: Gammon, Don B., Snoeck, Robert, Fiten, Pierre, Krečmerová, Marcela, Holý, Antonín, De Clercq, Erik, Opdenakker, Ghislain, Evans, David H., Andrei, Graciela
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2008
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593306/
https://ncbi.nlm.nih.gov/pubmed/18842735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01528-08
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