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Mechanism of Antiviral Drug Resistance of Vaccinia Virus: Identification of Residues in the Viral DNA Polymerase Conferring Differential Resistance to Antipoxvirus Drugs

The acyclic nucleoside phosphonate (ANP) family of drugs shows promise as therapeutics for treating poxvirus infections. However, it has been questioned whether the utility of these compounds could be compromised through the intentional genetic modification of viral sequences by bioterrorists or the...

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Detalhes bibliográficos
Main Authors: Gammon, Don B., Snoeck, Robert, Fiten, Pierre, Krečmerová, Marcela, Holý, Antonín, De Clercq, Erik, Opdenakker, Ghislain, Evans, David H., Andrei, Graciela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593306/
https://ncbi.nlm.nih.gov/pubmed/18842735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01528-08
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