Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus

Cidofovir or (S)-HPMPC is one of the three antiviral drugs that might be used for the treatment of orthopoxvirus infections. (S)-HPMPC and its 2,6-diaminopurine counterpart, (S)-HPMPDAP, have been described to select, in vitro, for drug resistance mutations in the viral DNA polymerase (E9L) gene of...

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Hlavní autoři: Duraffour, Sophie, Andrei, Graciela, Topalis, Dimitri, Krečmerová, Marcela, Crance, Jean-Marc, Garin, Daniel, Snoeck, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416337/
https://ncbi.nlm.nih.gov/pubmed/22532673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00355-12
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