Evaluation of Novel Acyclic Nucleoside Phosphonates against Human and Animal Gammaherpesviruses Revealed an Altered Metabolism of Cyclic Prodrugs upon Epstein-Barr Virus Reactivation in P3HR-1 Cells

Acyclic nucleoside phosphonates (ANPs), such as (S)-1-[(3-hydroxy-2-phosphonomethoxy)propyl)]cytosine (HPMPC), are an important group of broad-spectrum antiviral agents with activity against DNA viruses. In this report, we present the in vitro potencies of novel ANPs against gammaherpesviruses, incl...

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Bibliografiske detaljer
Main Authors: Coen, Natacha, Duraffour, Sophie, Naesens, Lieve, Krečmerová, Marcela, Van den Oord, Joost, Snoeck, Robert, Andrei, Graciela
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807898/
https://ncbi.nlm.nih.gov/pubmed/24027315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02231-13
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