Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A(1) receptors of LUF5831, a novel nonadenosine-like agonist

1. The interaction of a new nonribose ligand (LUF5831) with the human adenosine A(1) receptor was investigated in the present study. 2. Radioligand binding experiments were performed in the absence and presence of diverse allosteric modulators on both wild-type (wt) and mutant (T277A) adenosine A(1)...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Heitman, Laura H, Mulder-Krieger, Thea, Spanjersberg, Ronald F, von Frijtag Drabbe Künzel, Jacobien K, Dalpiaz, Alessandro, IJzerman, Adriaan P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2006
Teme:
Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1616979/
https://ncbi.nlm.nih.gov/pubmed/16444290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706655
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki