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PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2

Excessive bone loss in arthritic diseases is mostly due to abnormal activation of the immune system leading to stimulation of osteoclasts. While phospholipase Cγ (PLCγ) isoforms are known modulators of T and B lymphocyte–mediated immune responses, we found that blockade of PLCγ enzymatic activity al...

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Detalhes bibliográficos
Main Authors: Mao, Dailing, Epple, Holly, Uthgenannt, Brian, Novack, Deborah V., Faccio, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1616195/
https://ncbi.nlm.nih.gov/pubmed/17053833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28775
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