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Phospholipase Cγ2 Modulates Integrin Signaling in the Osteoclast by Affecting the Localization and Activation of Src Kinase

Integrin engagement induces a cascade of signaling pathways that include tyrosine phosphorylation of numerous proteins that lead to modulation of the actin cytoskeleton. Src is a major intracellular mediator of integrin-dependent functions, but the mechanism(s) by which Src is regulated in response...

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Bibliografiske detaljer
Main Authors: Epple, Holly, Cremasco, Viviana, Zhang, Kaihua, Mao, Dailing, Longmore, Gregory D., Faccio, Roberta
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423304/
https://ncbi.nlm.nih.gov/pubmed/18378693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00259-08
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