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Blood–brain equilibration kinetics of levo-α-acetyl-methadol using a chronically instrumented sheep preparation
1. The delayed onset and long duration of action of the opioid agonist levo-α-acetyl-methadol (LAAM) has been attributed to the formation of active metabolites. However, at present, little is known about the time course of blood–brain equilibration of LAAM itself. 2. The cerebral kinetics of LAAM we...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1615857/ https://ncbi.nlm.nih.gov/pubmed/16299549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706470 |
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