Blood–brain equilibration kinetics of levo-α-acetyl-methadol using a chronically instrumented sheep preparation

1. The delayed onset and long duration of action of the opioid agonist levo-α-acetyl-methadol (LAAM) has been attributed to the formation of active metabolites. However, at present, little is known about the time course of blood–brain equilibration of LAAM itself. 2. The cerebral kinetics of LAAM we...

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Detalhes bibliográficos
Main Authors: Foster, David J R, Jensen, Mette L, Upton, Richard N, Somogyi, Andrew A, Grant, Cliff, Martinez, Allison
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615857/
https://ncbi.nlm.nih.gov/pubmed/16299549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706470
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