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Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer’s Disease

According to the “amyloid hypothesis of Alzheimer’s disease,” β-amyloid is the primary driving force in Alzheimer’s disease pathogenesis. Despite the development of many transgenic mouse lines developing abundant β-amyloid-containing plaques in the brain, the actual link between amyloid plaques and...

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Main Authors: Schmitz, Christoph, Rutten, Bart P. F., Pielen, Andrea, Schäfer, Stephanie, Wirths, Oliver, Tremp, Günter, Czech, Christian, Blanchard, Veronique, Multhaup, Gerd, Rezaie, Payam, Korr, Hubert, Steinbusch, Harry W. M., Pradier, Laurent, Bayer, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615337/
https://ncbi.nlm.nih.gov/pubmed/15039236
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