Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer’s Disease

According to the “amyloid hypothesis of Alzheimer’s disease,” β-amyloid is the primary driving force in Alzheimer’s disease pathogenesis. Despite the development of many transgenic mouse lines developing abundant β-amyloid-containing plaques in the brain, the actual link between amyloid plaques and...

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Auteurs principaux: Schmitz, Christoph, Rutten, Bart P. F., Pielen, Andrea, Schäfer, Stephanie, Wirths, Oliver, Tremp, Günter, Czech, Christian, Blanchard, Veronique, Multhaup, Gerd, Rezaie, Payam, Korr, Hubert, Steinbusch, Harry W. M., Pradier, Laurent, Bayer, Thomas A.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2004
Sujets:
Animal Model
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615337/
https://ncbi.nlm.nih.gov/pubmed/15039236
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