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Weak Mutators Can Drive the Evolution of Fluoroquinolone Resistance in Escherichia coli
Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the “evolvability of fluoroquinolone resistance” are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone r...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1610101/ https://ncbi.nlm.nih.gov/pubmed/17005830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00783-06 |
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