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Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design
HTP (human thymidine phosphorylase), also known as PD-ECGF (platelet-derived endothelial cell growth factor) or gliostatin, has an important role in nucleoside metabolism. HTP is implicated in angiogenesis and apoptosis and therefore is a prime target for drug design, including antitumour therapies....
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Portland Press Ltd.
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1609907/ https://ncbi.nlm.nih.gov/pubmed/16803458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060513 |
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