Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design

HTP (human thymidine phosphorylase), also known as PD-ECGF (platelet-derived endothelial cell growth factor) or gliostatin, has an important role in nucleoside metabolism. HTP is implicated in angiogenesis and apoptosis and therefore is a prime target for drug design, including antitumour therapies....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Omari, Kamel EL, Bronckaers, Annelies, Liekens, Sandra, Pérez-Pérez, Maria-Jésus, Balzarini, Jan, Stammers, David K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Portland Press Ltd. 2006
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1609907/
https://ncbi.nlm.nih.gov/pubmed/16803458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060513
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