Peroxisomal Multifunctional Protein-2 Deficiency Causes Motor Deficits and Glial Lesions in the Adult Central Nervous System

In humans, mutations inactivating multifunctional protein-2 (MFP-2), and thus peroxisomal β-oxidation, cause neuronal heterotopia and demyelination, which is clinically reflected by hypotonia, seizures, and death within the first year of life. In contrast, our recently generated MFP-2-deficient mice...

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Bibliographic Details
Main Authors: Huyghe, Steven, Schmalbruch, Henning, Hulshagen, Leen, Veldhoven, Paul Van, Baes, Myriam, Hartmann, Dieter
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2006
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606565/
https://ncbi.nlm.nih.gov/pubmed/16565505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.041220
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