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Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system
BACKGROUND: Mice with peroxisome deficiency in neural cells (Nestin-Pex5(−/−)) develop a neurodegenerative phenotype leading to motor and cognitive disabilities and early death. Major pathologies at the end stage of disease include severe demyelination, axonal degeneration and neuroinflammation. We...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3419640/ https://ncbi.nlm.nih.gov/pubmed/22458306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-61 |
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