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Absence of 12/15 Lipoxygenase Reduces Brain Oxidative Stress in Apolipoprotein E-Deficient Mice

The enzyme 12/15 lipoxygenase (12/15LO) has been implicated in the oxidative modification of lipoproteins and phospholipids in vivo. In addition, mice deficient in apolipoprotein E (ApoE(−/−)) are characterized by spontaneous hypercholesterolemia and a systemic increase in oxidative stress. Whereas...

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Bibliografiske detaljer
Main Authors: Chinnici, Cinzia M., Yao, Yuemang, Ding, Tao, Funk, Colin D., Praticò, Domenico
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603776/
https://ncbi.nlm.nih.gov/pubmed/16251421
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