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Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice

Atherosclerosis may be viewed as an inflammatory disease process that includes early oxidative modification of LDLs, leading to foam cell formation. This “oxidation hypothesis” has gained general acceptance in recent years, and evidence for the role of lipoxygenases in initiation of, or participatio...

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Main Authors: Cyrus, Tillmann, Witztum, Joseph L., Rader, Daniel J., Tangirala, Rajendra, Fazio, Sergio, Linton, MacRae F., Funk, Colin D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC408369/
https://ncbi.nlm.nih.gov/pubmed/10359569
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