Deregulation of the Phosphatidylinositol-3 Kinase Signaling Cascade Is Associated with Neurodegeneration in Npc1−/− Mouse Brain

Niemann-Pick type C (NPC) disease is caused by mutations to genes that encode proteins critical to intracellular lipid homeostasis. The events underlying NPC progressive neurodegeneration are poorly understood but include neurofibrillary tangles of the type found in Alzheimer’s disease. Here we inve...

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Autors principals: Bi, Xiaoning, Liu, Jihua, Yao, Yueqin, Baudry, Michel, Lynch, Gary
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2005
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Original Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603683/
https://ncbi.nlm.nih.gov/pubmed/16192643
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