Lung Alveolar Septation Defects in Ltbp-3-Null Mice

Latent transforming growth factor (TGF)-β binding proteins (LTBPs) modulate the secretion and activation of latent TGF-β. To explore LTBP function in vivo, we created an Ltbp-3(−/−) mouse that has developmental emphysema with decreased septation in terminal alveoli. Differences in distal airspace en...

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Bibliographic Details
Main Authors: Colarossi, Cristina, Chen, Yan, Obata, Hiroto, Jurukovski, Vladimir, Fontana, Laura, Dabovic, Branka, Rifkin, Daniel B.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2005
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603559/
https://ncbi.nlm.nih.gov/pubmed/16049328
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