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Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome

Marfan syndrome (MFS) is an autosomal dominant disorder of connective tissue, caused by mutations of the microfibrillar protein fibrillin-1, that predisposes affected individuals to aortic aneurysm and rupture and is associated with increased TGFβ signaling. TGFβ is secreted from cells as a latent c...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zilberberg, Lior, Phoon, Colin K. L., Robertson, Ian, Dabovic, Branka, Ramirez, Francesco, Rifkin, Daniel B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653215/
https://ncbi.nlm.nih.gov/pubmed/26494287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507652112
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