FGF2 Binding, Signaling, and Angiogenesis Are Modulated by Heparanase in Metastatic Melanoma Cells

Heparanase (HPSE) and fibroblast growth factor-2 (FGF2) are critical regulators of melanoma angiogenesis and metastasis. Elevated HPSE expression contributes to melanoma progression; however, further augmentation of HPSE presence can inhibit tumorigenicity. HPSE enzymatically cleaves heparan sulfate...

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Autors principals: Reiland, Jane, Kempf, Doty, Roy, Madhuchhanda, Denkins, Yvonne, Marchetti, Dario
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2006
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1601937/
https://ncbi.nlm.nih.gov/pubmed/16867222
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