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Modulation of GEF-H1 Induced Signaling by Heparanase in Brain Metastatic Melanoma Cells

Mechanisms of brain metastatic melanoma (BMM) remain largely unknown. Understanding the modulation of signaling pathways that alter BMM cell invasion and metastasis is critical to develop new therapies for BMM. Heparanase has been widely implicated in cancer and is the dominant mammalian endoglycosi...

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Bibliografiske detaljer
Main Authors: Ridgway, Lon D., Wetzel, Michael D., Marchetti, Dario
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007595/
https://ncbi.nlm.nih.gov/pubmed/20803552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22854
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