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Heparanase – induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells
Heparanase (HPSE) is the only mammalian endoglycosidase which has been widely implicated in cancer because of its capability to degrade heparan sulfate chains (HS) of HS proteoglycans (HSPGs). Specifically, the cell surface HSPG syndecans 1 and 4 (SDC1 and SDC4) are modulators of growth factor actio...
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| Опубликовано в: : | Mol Cancer Res |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5524200/ https://ncbi.nlm.nih.gov/pubmed/22513363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0534 |
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