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Heparanase – induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells

Heparanase (HPSE) is the only mammalian endoglycosidase which has been widely implicated in cancer because of its capability to degrade heparan sulfate chains (HS) of HS proteoglycans (HSPGs). Specifically, the cell surface HSPG syndecans 1 and 4 (SDC1 and SDC4) are modulators of growth factor actio...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Ridgway, Lon D., Wetzel, Michael D., Ngo, Jason A., Erdreich-Epstein, Anat, Marchetti, Dario
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524200/
https://ncbi.nlm.nih.gov/pubmed/22513363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0534
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