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Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
HIV-1 enters cells by membrane fusion, mediated by the trimeric viral envelope glycoprotein gp160, which is processed by a single proteolytic cleavage into stably associated gp120 and gp41. The gp120/gp41 trimer can be triggered to undergo an irreversible conformational change. Using a protein-based...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1599892/ https://ncbi.nlm.nih.gov/pubmed/16963566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601036103 |
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