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Disulfide isomerization switches tissue factor from coagulation to cell signaling

Cell-surface tissue factor (TF) binds the serine protease factor VIIa to activate coagulation or, alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor 2 (PAR2) relevant to inflammation and angiogenesis. Here we demonstrate that TF·VIIa-mediated coagulation a...

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Detalhes bibliográficos
Main Authors: Ahamed, Jasimuddin, Versteeg, Henri H., Kerver, Marjolein, Chen, Vivien M., Mueller, Barbara M., Hogg, Philip J., Ruf, Wolfram
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599891/
https://ncbi.nlm.nih.gov/pubmed/16959886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606411103
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