Protease activated receptor (PAR) 2, but not PAR1 signaling promotes the development of mammary adenocarcinoma in PyMT mice

The G protein-coupled protease activated receptors (PARs) are key signaling components for proteases in vascular biology and tumor progression. In order to address the contributions of PAR1 and PAR2 to breast cancer development, we established cohorts of MMTV-PyMT PAR1−/− and PAR2−/− mice, consideri...

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Bibliographic Details
Main Authors: Versteeg, Henri H., Schaffner, Florence, Kerver, Marjolein, Ellies, Lesley G., Patricia, Andrade-Gordon, Mueller, Barbara M., Ruf, Wolfram
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596617/
https://ncbi.nlm.nih.gov/pubmed/18757438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0419
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