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Protease activated receptor (PAR) 2, but not PAR1 signaling promotes the development of mammary adenocarcinoma in PyMT mice
The G protein-coupled protease activated receptors (PARs) are key signaling components for proteases in vascular biology and tumor progression. In order to address the contributions of PAR1 and PAR2 to breast cancer development, we established cohorts of MMTV-PyMT PAR1−/− and PAR2−/− mice, consideri...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596617/ https://ncbi.nlm.nih.gov/pubmed/18757438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0419 |
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