Apc Mutation Enhances PyMT-Induced Mammary Tumorigenesis

The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation; however, the cooperation between APC and other mut...

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Bibliografiske detaljer
Main Authors: Prosperi, Jenifer R., Khramtsov, Andrey I., Khramtsova, Galina F., Goss, Kathleen H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245255/
https://ncbi.nlm.nih.gov/pubmed/22216254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029339
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