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Apc Mutation Enhances PyMT-Induced Mammary Tumorigenesis
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation; however, the cooperation between APC and other mut...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245255/ https://ncbi.nlm.nih.gov/pubmed/22216254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029339 |
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