Postexposure vaccination massively increases the prevalence of γ-herpesvirus-specific CD8(+) T cells but confers minimal survival advantage on CD4-deficient mice

Mice that lack CD4(+) T cells remain clinically normal for more than 60 days after respiratory challenge with the murine γ-herpesvirus 68 (γHV-68), then develop symptoms of a progressive wasting disease. The γHV-68-specific CD8(+) T cells that persist in these I-A(b−/−) mice are unable to prevent co...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Belz, Gabrielle T., Stevenson, Philip G., Castrucci, Maria R., Altman, John D., Doherty, Peter C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15997/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10694575/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040575197
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